TORU Lab has designed and led a project in collaboration with orthopaedic surgeons on sampling, banking and miRNA/mRNA sequencing of the patients’ blood and bone tissue. The project has identified exosomal miRNAs as regulators of mRNAs in osteolysis of the patients undergoing revision total joint replacement (TJR). Dr Yi Deng, our PhD student, and a surgeon on Australian Orthopaedic Association Fellowship Accreditation Program, is working on this project. To date, he has collected and sequenced over patients’ samples, and currently expanding the project to seek national and international participants for big database and modelling aiming to have 300 patients recruited. This program will provide better understanding of mRNA related to aberrantly expressed miRNAs, which would be drug targets.

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